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Jen Gallagher
Department of Biology


Amuary Pupo,, Michael C. Ayers, Zachary N. Sherman, Rachel J. Vance, Jonathan R. Cumming and Jennifer E.G. Gallagher. 2019. MCHM Acts as a Hydrotrope, Altering the Balance of Metals in Yeast. In Press Biological Trace Elements Research MCHM hydrotrope

Signficance: Hydrotropes increase the solubility of compounds and induce liquid phase transitions. MCHM acts as a hydrotrope in vitro and in vivo changes the expression of metal transport genes causing zinc and iron levels to increase.

Jennifer E.G. Gallagher. Proteins and RNA sequences required for the transition of the t-Utp complex into the SSU processome. 2019 FEMS Yeast Research. Jan 1:19(1). SSU processome maturation 

Signficance: The transcription associated UTP proteins associate to the growing pre-rRNA first.

Xiaoqing Rong-Mullins, Michael C. Ayers‡, Mahmoud SummersƗ, and Jennifer E.G. Gallagher. Transcriptional profiling of S. cerevisiae reveals the impact of variation of a single transcription factor on differential gene expression in 4NQO, fermentable, and non-fermentable carbon sources. 2018 G3: Genes, Genomes, Genetics Feb 1: 892, 607-619. Yrr1 and 4NQO

Significance: Major mechanism of 4NQO toxicity is ROS production during respiration-dependent metabolism.

Xiaoqing Rong-Mullins, Apoorva Ravishankar, Kirsten A. McNeal*, Zachery R. Lonergan*, J. Philip Creamer*, Audrey C. Biega*, and Jennifer E.G. Gallagher. Genetic variation in Dip5, an amino acid permease, and Pdr5, a multiple drug transporter, regulates glyphosate resistance in S. cerevisiae. PLoS One Nov 20;12(11):e0187522. doi: 10.1371/journal.pone.0187522 Dip5 and Pdr5

Significance: Discovered the import and export pathways of the herbicide, RoundUp into yeast. 

Xiaoqing Rong-Mullins, Matthew Winans, Justin B. Lee, Zachary R. Lonergan, Lyndsey M. Weatherly, Thomas W. Carmenzind, Lihua Jiang, Jonathan R. Cumming, Gloria Oporto, Jennifer E. G. Gallagher. 2017 Proteomic and genetic analysis of S. cerevisiae response to soluble copper leads to improvement of antimicrobial function of cellulosic copper nanoparticles. 2017 Metallomics 9 (9) 1304-1315. doi: 10.1039/C7MT00147A  c-CuNP paper

Significance: Modulating the balance between copper and zinc to alter the sensitivity to antimicrobial hybrid-metal nanomaterials.

Jennifer Weidhaas, A.M. Dietrich, W. Foreman, D. Gallagher, J.E.G. Gallagher, A. Whelton, W. Alexander. Enabling science support during incident response for better decision making. 2016 Journal of Environmental Quality 45 (5) 1490-1500 doi: 10.2134/jeq2016.03.0090 MCHM response

Significance: Commentary on the coordination between the governmental regulatory agency and the academic community during environmental spills: a case study of the Elk River MCHM spill.

Giltae Song, Benjamin J. A. Dickins, Janos Demeter, Stacia Engel, Jennifer Gallagher, Kisurb Choe, Barbara Dunn, Michael Snyder, and J. Michael Cherry. AGAPE (Automated Genome Analysis PipelinE) for Pan-Genome Analysis of Saccharomyces cerevisiae. PLoS ONE 10(5): e0129184. doi: 10.1371/journal.pone.0129184 Yeast Genomes

Significance: Resequencing and genome assembly of genetically diverse yeast strains.

Jennifer E.G. Gallagher, Wei Zheng, Noraliz Miranda, Zhixiang Lin, Hongyu Zhao and Michael Snyder. Natural genetic variations in populations indicates regulation of phenotypes and transcriptional responses by master variators. 2014. Genes & Development Feb 15, 2014 28:409-421. Yrr1 TF

Significance: Identified polymorphisms in a single transcription factor that acted as switch in fitness between two different environments by rewiring gene regulatory networks.

Michael P. Snyder and Jennifer E.G. Gallagher. Systems Biology from a Yeast Omics Perspective. 2009 FEBS letters. Dec 1;5839240:3895-9.

Significance: Review of historical and current genomics, proteomics and other large-scale systems biology technology primarily developed in yeast.

Gallagher and Snyder 2009